The Effectiveness of Low-dose Ketamine Versus Pethidine for Prevention of Postoperative Shivering after Spinal Anesthesia : A Randomized Control Trial

Abstract

     This research aimed to compare the effectiveness of low-dose ketamine versus pethidine for prevention of postoperative shivering after spinal anesthesia. There was quasi experiment by doubleblinded, randomized controlled trial, 66 patients undergoing surgery under spinal anesthesia were randomly allocated to 2 groups; group A(n=33) received 0.4 mg/kg of pethidine, and group B(n=33) received 0.25 mg/kg of ketamine. The study medications were diluted with NSS up to 3 ml and then administered within 20 minutes of the estimated end of surgery. Shivering was evaluated using the Crossley and Mahajan scale at 0, 10, 20 and 30 minutes after arriving in the recovery room.     

     Results: There was no significantly different incidence of shivering among groups A and B. At 0
minutes, the incidence was 9.1% versus 18.2% (OR = 0.45, 95%CI: 0.10 - 1.98, p-value = 0.290), at 10 minutes,
it was 6.1% versus 18.2% (OR = 0.29, 95%CI: 0.05 - 1.56, p-value = 0.149), at 20 minutes, it was 6.1% versus 12.1% (OR = 0.47, 95%CI: 0.08 - 2.75, p-value = 0.400), and incidence of adverse effects of study medications
is 12.1% vs. 6.1% (p-value = 0.672).