Ten-Year Review of Methotrexate toxicity at Maharat Nakorn Ratchasima Hospital.
Keywords:
Methotrexate toxicity, Pancytopenia, Acute kidney injury, Hepatotoxicity, MortalityAbstract
This study aimed to investigate the baseline characteristics, complications, and laboratory parameters associated with mortality in patients with methotrexate toxicity. This retrospective descriptive study reviewed the medical records of 110 patients diagnosed with MTX toxicity at Maharat Nakhon Ratchasima Hospital between January 1, 2015, and December 31, 2024. Patients were categorized into two groups: survivors (n=100) and non-survivors (n=10). Data on baseline characteristics, medication errors, complications, and laboratory results were collected. Comparative analysis was performed using the independent t-test for normally distributed data, the Wilcoxon-Mann-Whitney test for non-normally distributed data, and Fisher’s exact test for categorical variables.
Results: Common complications included pancytopenia, acute kidney injury, and abnormal liver function. Laboratory analysis revealed that the non-survivor group had significantly lower platelet counts and significantly higher creatinine and AST levels compared to the survivor group (p=0.01). Albumin levels tended to be lower in the non-survivor group (p=0.05). No statistically significant differences were found in hematocrit, white blood cell count, ALT, or ALP levels. Medication error was not significantly associated with mortality (p=0.310).
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