The Effectiveness of Red Orange Extract (REDORY™) in Reducing UVB-Induced Hyperpigmentation
Keywords:
red orange extract, REDORY™, UVB radiation, hyperpigmentation, Melanin indexAbstract
This study was a randomized controlled clinical trial with participant and evaluator blinding (double-blind) involving 20 Thai volunteers. The volunteers received REDORY™ Facial Serum and a placebo serum on the inner upper arm continuously for three weeks before UVB irradiation and were followed up at weeks 0, 3, 4, and 7. The assessment tools included a Colorimeter for measuring skin lightness and a Mexameter for measuring the Melanin index and Erythema index. Data were analyzed using linear mixed-effects models.
The between-group comparison showed no statistically significant differences in all parameters at all time points (p > 0.05). Within the REDORY™ Facial Serum group, at week 3, the Colorimeter value increased significantly compared with week 0 (p < 0.001). After UVB irradiation, at week 4, the Colorimeter value decreased significantly (p = 0.029), while the Melanin index and Erythema index increased significantly (p < 0.001 and p = 0.001, respectively). At week 7, all three parameters remained higher than those at week 3. The Colorimeter value did not show a statistically significant difference, whereas the Melanin index and Erythema index showed statistically significant differences (p = 0.009 and p = 0.017, respectively). In the placebo serum group, the results were consistent in the same direction across all three parameters.
References
Hasegawa K, Fujiwara R, Sato K, et al. Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in Both Human Facial Solar Lentigines and Melasma. Ann Dermatol. 2015;27(5):626-634. doi: 10.5021/AD.2015.27.5.626.
Kim HS. A Study on the Trends of the Natural UV Protection Materials Related to Skin Beauty. Journal of the Korean Applied Science and Technology. 2021;38(1):107-17.
Giacomoni PU. Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide, and Singlet Oxygen. Antioxidants (Basel). 2020;9(11):1091. doi: 10.3390/ANTIOX9111091.
Puglia C, Offerta A, Saija A, Trombetta D, Venera C. Protective effect of red orange extract supplementation against UV‐induced skin damages: photoaging and solar lentigines. Journal of cosmetic dermatology. 2014 Jun;13(2):151-7.
Gilchrest BA, Park HY, Eller MS, Yaar M. Mechanisms of ultraviolet light-induced pigmentation. Photochem Photobiol [Internet]. 2012 [ cited 2024 July 2]; 63(1) :1-10. Available from https://pubmed.ncbi.nlm.nih.gov/8577860/. doi : 10.1111/j.1751-1097.1996.tb02988.x.
Jian Q, An Q, Zhu D, Hui K, Liu Y, Chi S, et al. MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes. Indian J Dermatol Venereol Leprol [Internet]. 2012 [ cited 2024 July 2] ; 78(4):417-28. Available from https://pubmed.ncbi.nlm.nih.gov/22772611/. doi: 10.4103/0378-6323.98071.
Xing X, Dan Y, Xu Z, Xiang L. Implications of oxidative stress in the pathogenesis and treatment of hyperpigmentation disorders. Oxid Med Cell Longev. 2022;2022:7881717. doi:10.1155/2022/7881717.
Hollinger JC, Angra K, Halder RM. Are natural ingredients effective in the management of hyperpigmentation? A systematic review. J Clin Aesthet Dermatol. 2018;11(2):28–37.
Medinutrex. Certificate of Analysis: REDORY™ (Red orange extract). Compilation date: 11 June 2024. Italy: Medinutrex; 2024.
Burò I, Consoli V, Castellano A, Vanella L, Sorrenti V. Beneficial effects of standardized extracts from wastes of red oranges and olive leaves. Antioxidants. 2022 Jul 30;11(8):1496.
Nobile V, Burioli A, Yu S, Zhifeng S, Cestone E, Insolia V, Zaccaria V, Malfa GA. Photoprotective and antiaging effects of a standardized red orange (Citrus sinensis (L.) Osbeck) extract in asian and caucasian subjects: A randomized, double-blind, controlled study. Nutrients. 2022 Jan;14(11):2241.
Tomasello B, Malfa GA, Acquaviva R, La Mantia A, Di Giacomo C. Phytocomplex of a standardized extract from red orange (Citrus sinensis L. Osbeck) against photoaging. Cells. 2022 Apr 25;11(9):1447.
Ullrich SE. Sunlight and skin cancer: lessons from the immune system. HHS Author Manuscripts [Internet]. 2007[ cited 2024 July 2];46(8):629-33. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661262/. doi : 1-.1002/mc.20328.
Viyoch Jarupa, Mahingsa Khuanrudee, Ingkaninan Kornkanok. Effects of Thai Musa species on prevention of UVB induced skin damage in mice. Food Chem Toxicol [Internet] 2012 [cited 2024 July 2] ;50(12):4292-301. Available from https://pubmed.ncbi.nlm.nih.gov/22986089/ doi: 10.1016/j.fct.2012.08.060.
Streilein JW. Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol [Internet]. 1983 [ cited 2024 July 2] ;80 Suppl:12S-16S. Available from https://pubmed.ncbi.nlm.nih.gov/6602189/. doi: 10.1111/1523-1747.
Noonan FP, Kripke ML, Pederson GM, Greene MI. Suppression of contact hypersensitivity in mice by ultraviolet irradiation is associated with defective antigen presentation. Immunology [Internet]. 1981[ cited 2024 July 3] ;43(3):527-33. Available from https://pubmed.ncbi.nlm.nih.gov/7251064/.
Battie C, Jitsukawa S, Bernerd F, Del Bino S, Marionnet C, Verschoore M. New insights in photoaging, UVA induced damage and skin types. Exp Dermatol [Internet]. 2014 [ cited 2024 July 3];23 Suppl 1:7-12. Available from https://pubmed.ncbi.nlm.nih.gov/25234829/. doi: 10.1111/exd.12388.
ศักดิ์ชาย ขัติยา. ประสิทธิผลของการพัฒนาระบบบริบาลทางเภสัชกรรม ในคลินิกกัญชาทางการแพทย์ แผนไทย ณ โรงพยาบาลห้วยเกิ้ง จ. อุดรธานี. วารสารสิ่งแวดล้อมศึกษาการแพทย์ และสุขภาพ. 2022 Dec 13;7(4):24-39.
ธีวรา โลมรัตน์, ตุลาการ นาคพันธ์. การประเมิน ประสิทธิผลของยาฟาวิพิราเวียร์ในผู้ป่วยโควิด-19 ที่รับการรักษาในโรงพยาบาลกุดข้าวปุ้น จังหวัดอุบลราชธานี. วารสารสิ่งแวดล้อมศึกษาการแพทย์ และสุขภาพ. 2022 Jun 30;7(2).
จตุพร แพงจักร, พิจิตรา ยืนยั่ง, เศรษฐกุล บุญยศักดิ์ เสรี. ประสิทธิผลของการพอกเข่าด้วยสมุนไพร ในผู้สูงอายุที่มารับบริการ ณ โรงพยาบาลส่งเสริมสุขภาพตำบลบ้านน้ำโจน อำเภอเมือง จังหวัดตาก. วารสารสิ่งแวดล้อมศึกษาการแพทย์ และสุขภาพ. 2025 Dec 31;10(4):265-70.
Inthala N. The effectiveness of intravenous N-acetylcysteine injection on skin lightening and pigmentation intensity [Master’s thesis]. Bangkok (TH): Dhurakij Pundit University; 2023.
Woolery-Lloyd H, Kammer JN. Treatment of hyperpigmentation. Semin Cutan Med Surg. 2011;30(3):171-175. doi:10.1016/j.sder.2011.06.004.
