Accuracy of HPV DNA Testing for Cervical Cancer Screening in Krabi Hospital
Keywords:
Cervical cancer, HPV DNA testing, Self-collection, Physician-collectionAbstract
This study was retrospective study aimed to assess the accuracy of HPV DNA testing for cervical cancer screening between self-collected and physician-collected vaginal samples. A was conducted on 158 participants undergoing HPV DNA test screening at the Gynecology Department of Krabi Hospital between October 2023 and September 2024. Participants were divided into two groups: self-collected testing (SCT) and physician-collected testing (PCT). Data were analyzed using descriptive statistics, chi-square test, and calculations of sensitivity, specificity, positive predictive value, and negative predictive value.
Results: The mean age of participants was 45.98±7.96 years. High-risk HPV infection was detected in 54.43% of samples, including HPV type 16 (24.05%), HPV type 18 (8.86%), and combined HPV types 16 and 18 (21.52%). Pathological examination revealed abnormal cells in 31.63% of samples, with LSIL found in 17.72% and CIN III in 7.59%. LEEP procedure was performed on 10.13% of patients, and cervical cancer was identified in 3.16% (5 patients). In the physician-collected group, co-infection with HPV types 16 and 18 showed a statistically significant relationship with pathological abnormalities (CIN II-III) (p=0.032). Physician-collected sampling demonstrated higher accuracy compared to self-collection, with ROC area of 0.65 versus 0.34, sensitivity of 17.2%, and specificity of 94.7%.
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