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The purposes of this research were to develop and to implement the biology instructional model to enhance analytical thinking, critical thinking and problem solving thinking skills. The sample were forty-six Mathayomsuksa 6 students of Chonrasadornumrung School of the second semester 2016. The cluster random sampling method was used to select the sample. The research instruments were lesson plans based on the model, analytical thinking test, critical thinking test, problem solving thinking test, science achievement test and attitude towards biology subject test. The statistics used for data analysis were mean, standard deviation and t-test. The research results were as follows:
1. The developed biology instructional model for the enhancement of analytical thinking, critical thinking and problem solving thinking skills, comprised of four major components: 1) the principle, 2) the objectives, 3) the learning process (with eight stages : Stimulus Recall of Prior Learning, Objectives, Native Knowledge, Group Processing, Sharing, Expansion, Re-educate and Monitoring), and 4) the result of studying from the instructional model. The Evaluation of appropriate model by the experts was at the high level ( = 4.49).
2. The results of implementing the instructional model showed that the posttest scores of the students having analytical thinking test, critical thinking test, problem solving thinking test, biology achievement test were higher than the pretest at the .05 level of statistical significance. The attitude towards biology subject of the sample group after the learning by this instructional model was at the high level ( = 3.87).
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