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The objective of this research was to study how to teach using model-based learning to promote the development of scientific conceptions on organic compounds of 40 Grade 12 students, in a large secondary school in Lopburi province. The researcher used 4 cycles of classroom action research. The Model-Based Learning consists of 4 steps; 1) model generation, 2) model evaluation, 3) model modification, and 4) model elaboration, and carried out data collection using the teaching notes and scientific concept test. The researcher categorizing students’ responses into 5 categories and used content analysis and method triangulation to analyze and improve the teaching approach. The findings indicated that the teaching with model-based learning, the students showed more partial understanding than specific misconception. The students can writing, explaining, presenting, discussing and answering questions. The highest of sound understanding is carbon bonding and specific misconception is isomerism.
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