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An experimental study was conducted to test the effectiveness of clients-centered therapy (CCT) for the treatment of major depression. 30 women aged 15 to 55 reported with the main symptoms of major depression were randomly assigned to two groups; 15 treatment group and 15 waiting list as control group. The treatment group undergone four individual hourly therapy sessions within a period between 8 to 12 weeks. A one way ANOVA using the pre and post BDI assessment indicated significant effect of CCT (F = 8.71, p < .01, ES = .24) Follow up assessment was also conducted to observe the extent of therapy-client interaction effects. Qualitative data and subjective opinion of the subjects were also presented to support the results.Keywords: psychotherapy for women, major depression, experimental study
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