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This research was aimed to study how to manage learning based on socio-scientific issues that develop scientific reasoning ability for decision making on biomolecules unit of 12th grade students. There were 34 participants. This action research was run three cycles of PAOR. The instruments in this research was consisted in learning management plan, semi-structured learning observation, teacher’s reflective logs, students’ learning logs, and students’ activity sheets. The data were analyzed qualitatively by content analysis. The research was found that the learning management approach should be as follows: the situation should be short and compact. The issues should not be too difficult or complex. Which allow students to use their knowledge in problem solving and method-designing of survey, encourage students to reflect on the importance of reasoning by using valid and reliable evidences which support conclusions and judgements. In addition, a teacher always plays a role in motivating students to discuss their knowledge as a group in classes. The teacher makes an environment fun, relax, and not stressful which allow the students to express themselves. Moreover, after learning management, students developed more scientific reasoning ability for decision making, respectively.
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