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The purpose of this research was to compare health literacy between learning management using socio scientific issues in topic of immune system for grade 11 students. The sample group was grade 11 students in the large secondary schools in Phitsanulok province. The forty students participated from purposive sampling. Research instrument included 1) three lesson plans based on socio scientific issues in topic of the immune system, namely body prevention and elimination against infectious agents, immunization in body and disruptions in immune system, and 2) forms for health literacy assessment based on quasi-experimental research combined with time series design. The mean value and standard deviation were analyzed using t-test. The result of research was found that the total scores of all students who have been learning using socio scientific issues in topic of immune system has increased continuously throughout the three period of health literacy assessment with statistically significant at .05 level. The summative level of health behavior literacy stood at the second level. It meant that students had adequate health literacy and could prevent themselves from diseases.
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