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This action research aims to study the learning management of socio-scientific issue-based approach (SSI) for enhancing genetics literacy on topic of DNA technology and effect of SSI approach to enhancing genetics literacy of grade 10 students. The participants were 34 students. The research instruments consisted of 3 lesson plans using socio-scientific issue about application of DNA technology, reflective learning management form, worksheets and the assessment forms of genetics literacy. Data were analyzed using content analysis, average score and percentage. The level of genetics literacy of participants was divided into 3 levels by framework of Abrams et al. (2015) included low, medium, and high. The findings showed that the learning management using SSI approach to enhance genetics literacy on topic of DNA technology, that should choose the socio-scientific issues debated in society and relate to lesson and use role play activity for students to learn vocabularies, principles of genetics and synthesize knowledge into their practice on scientific and social issues. Additionally, the students’ genetics literacy level had progressed after learning through SSI approach from 13.73% to 76.00% (low to high level).
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