CYTOTOXICITY OF ALPINIA GALANGA RHIZOME EXTRACTS AND ISOLATED COMPOUNDS AGAINST SMALL CELL LUNG CANCER NCI-H187 CELL LINE
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บทคัดย่อ
The purpose of this research was to study the cytotoxicity of the extracts from Alpinia galanga rhizome and isolated compounds against NCI-H187 small cell lung cancer cells.
1'S-1'-acetocavical acetate (1), p-coumaryl diacetate (2), 1'S-1'-acetoxy-eugenol acetate (3), (S)-hydroxycavicol acetate (4), 4-hydroxycinnamaldehyde (5) and trans-p-acetoxycinnamyl alcohol (6) were isolated from the rhizomes of Alpinia galangal. The structures of the isolated compounds were characterized by spectroscopic techniques and comparison with the literature. Among them, the extracts, and compounds 1-5 displayed potent cytotoxic activity against human small cell lung cancer (NCI-H187) cells exhibiting >98% at the highest concentration
(50 μg). Compound 1 showed the highest cytotoxicity against NCI-H187 cells with 99.69% inhibition and IC50 of 4.61 μM, 1.68-fold higher than ellipticine.
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ลิขสิทธิ์บทความวิจัยที่ได้รับการตีพิมพ์เผยแพร่ในวารสารวิจัยและพัฒนา วไลยอลงกรณ์ ในพระบรมราชูปถัมภ์ ถือเป็นกรรมสิทธิ์ของสถาบันวิจัยและพัฒนา มหาวิทยาลัยราชภัฏวไลยอลงกรณ์ ในพระบรมราชูปถัมภ์ ห้ามนำข้อความทั้งหมดหรือบางส่วนไปพิมพ์ซ้ำ เว้นแต่จะได้รับอนุญาตจากมหาวิทยาลัยเป็นลายลักษณ์อักษร
ความรับผิดชอบ เนื้อหาต้นฉบับที่ปรากฏในวารสารวิจัยและพัฒนา วไลยอลงกรณ์ ในพระบรมราชูปถัมภ์ เป็นความรับผิดชอบของผู้นิพนธ์บทความหรือผู้เขียนเอง ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากเทคนิคการพิมพ์
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